Journal
CHEMICAL COMMUNICATIONS
Volume 46, Issue 32, Pages 5957-5959Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0cc01054e
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Funding
- Shanghai Pujiang Program [08PJ1403300]
- National Natural Science Foundation of China [20902018]
- Fundamental Research Funds for the Central Universities
- 111 project [B07023]
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A general and direct organocatalytic asymmetric vinylogous Michael reaction of c-butenolide with alpha,beta-unsaturated ketones was investigated with a multifunctional primary amine salt as catalyst. The reaction enables straightforward access toward synthetically versatile c-substituted butenolides from simple 2(5H)-furanone with satisfactory yields, diastereo- and enantioselectivities (up to 30 : 1 dr and 95-99% ee).
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