4.7 Article

DNA-bridged bioconjugation of fluorescent quantum dots for highly sensitive microfluidic protein chips

Journal

CHEMICAL COMMUNICATIONS
Volume 46, Issue 33, Pages 6126-6128

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c0cc01608j

Keywords

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Funding

  1. NSFC [20725516, 90913014, 30425020, 90813010, 60537030]
  2. MOST [2007CB936000]
  3. Major ST Program [2009ZX10004-301, 2009ZX10004-302]
  4. SMCST [08PJ14011, 0952nm04600]
  5. Shanghai Leading Academic Discipline Project [B113]

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A DNA-bridged strategy is used to facilely conjugate streptavidin (STV) to luminescent semiconductor quantum dots (QDs), which leads to convenient and stable QD-DNA-biotin-STV conjugates that serve as fluorescent nanoprobes for ultrasensitive detection of cancer biomarkers with a microfluidic protein chip.

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