4.7 Article

Transannular, decarboxylative Claisen rearrangement reactions for the synthesis of sulfur-substituted vinylcyclopropanes

Journal

CHEMICAL COMMUNICATIONS
Volume 46, Issue 27, Pages 4991-4993

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c0cc00976h

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Funding

  1. EPSRC [GR/T10268]
  2. Hoffmann-La Roche
  3. Pfizer

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Unsaturated epsilon-lactones bearing an alpha-arylsulfonyl or alpha-arylsulfoximinyl substituent undergo stereoselective transannular, decarboxylative Claisen rearrangement to give substituted vinylcyclopropanes.

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