4.7 Article

Flexible synthesis, structural determination, and synthetic application of a new C-1-symmetric chiral ammonium betaine

Journal

CHEMICAL COMMUNICATIONS
Volume 46, Issue 2, Pages 300-302

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b916627k

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Funding

  1. Astellas Foundation for Research on Metabolic Disorders
  2. Global COE program in Chemistry of Nagoya University
  3. Tatematsu Fundation

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A C-1-symmetric chiral ammonium betaine has been developed, and its intramolecular ion-pairing structure in solid state and its catalytic performance to achieve the highly stereoselective Mannich-type reaction of 2-alkoxythiazol-5(4H)-ones are revealed.

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