4.7 Article

SERS mapping of nanoparticle labels in single cells using a microfluidic chip

Journal

CHEMICAL COMMUNICATIONS
Volume 46, Issue 42, Pages 7921-7923

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c0cc02209h

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Funding

  1. EPSRC (RCUK) [EP/E032745/1]
  2. BBSRC (Rasor IRC)
  3. EPSRC [EP/E032745/1] Funding Source: UKRI
  4. Biotechnology and Biological Sciences Research Council [BB/C511572/1] Funding Source: researchfish
  5. Engineering and Physical Sciences Research Council [EP/E032745/1] Funding Source: researchfish

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We report for the first time the time-resolved mapping of intracellular nanoparticle labels from within living cells retained in a microstructured trap using Raman spectroscopy. The methods employed here also demonstrate the ability to rapidly discriminate between cell populations containing different SERS labels.

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