4.7 Article

A novel degradable polymeric carrier for selective release and imaging of magnetic nanoparticles

Journal

CHEMICAL COMMUNICATIONS
Volume 46, Issue 36, Pages 6708-6710

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c0cc01857k

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Funding

  1. National Natural Science Foundation of China [20876101, 20902065]
  2. Natural Science Foundation of Jiangsu Province [BK2008158]
  3. Supporting Project of Jiangsu Province (Industry) [BE2008061]
  4. Soochow University [Q3122845]

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A water-soluble, pH-responsive copolymer was synthesized successfully and used as a polymeric carrier to deliver hydrophobic paramagnetic nanoparticles into cells. In an acidic environment, the nanoparticles aggregate as the copolymer degrades, resulting in the enhancement of an in vitro MRI signal.

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