4.7 Article

Oxindole synthesis by palladium-catalysed aromatic C-H alkenylation

Journal

CHEMICAL COMMUNICATIONS
Volume 46, Issue 14, Pages 2462-2464

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b926560k

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A strategy involving palladium-catalysed aromatic C-H functionalisation/ intramolecular alkenylation provides a convenient and direct synthesis of 3-alkylideneoxindoles. In the presence of 5 mol% of PdCl2MeCN2 and AgOCOCF3, a wide variety of N-cinnamoylanilines gave 3-alkylideneoxindoles in moderate to good yield.

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