4.7 Article

Responsive and mitochondria-specific ruthenium(II) complex for dual in vitro applications: two-photon (near-infrared) induced imaging and regioselective cell killing

Journal

CHEMICAL COMMUNICATIONS
Volume 46, Issue 36, Pages 6678-6680

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c0cc01848a

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Funding

  1. Research Grants Council of the Hong Kong SAR, P. R. China [HKBU 202308, HKBU 202509]
  2. Hong Kong Baptist University [FRG2/08-09/067]

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A mitochondria-permeable ruthenium(II) complex has been designed as a responsive probe which may be used to sensitize the formation of singlet oxygen (Phi(Delta) = 0.93) and cause local damage in cellulo when exposed to UV and near-infrared laser excitation.

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