Journal
CHEMICAL COMMUNICATIONS
Volume 46, Issue 48, Pages 9116-9118Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0cc02917c
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Funding
- CRUK
- FNRS
- COST Action [MP0802]
- University of Liege [D-08/10]
- EPSRC [EP/E059643/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/E059643/1] Funding Source: researchfish
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A library of triazole-based telomeric quadruplex-selective ligands has been developed that mimic an established family of tri-substituted acridine-based ligands, using crystal structure data as a starting-point for computer-based design. Binding affinities, estimated by electrospray mass spectrometry, are in accord with the design concept.
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