4.7 Article

Highly organocatalytic asymmetric Michael-ketone aldol-dehydration domino reaction: straightforward approach to construct six-membered spirocyclic oxindoles

Journal

CHEMICAL COMMUNICATIONS
Volume 46, Issue 42, Pages 8064-8066

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c0cc03032e

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Funding

  1. National Natural Science Foundation of China [20802075]

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An efficient Michael-ketone aldol-dehydration domino reaction has been developed to afford spiro[cyclohex-2-enone-oxindole] motifs with high yields (up to 99%), excellent diastereo-selectivities (dr > 20:1) and enantioselectivities (up to 96% ee).

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