4.7 Article

Pyrene-functionalized triazole-linked 2 '-deoxyuridines-probes for discrimination of single nucleotide polymorphisms (SNPs)

Journal

CHEMICAL COMMUNICATIONS
Volume 46, Issue 27, Pages 4929-4931

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c0cc01133a

Keywords

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Funding

  1. Idaho NSF EPSCoR
  2. BANTech Center at Univ. of Idaho
  3. University of Idaho Research Office and Research Council
  4. College of Graduate Studies, Univ. of Idaho

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Oligonucleotides modified with pyrene-functionalized triazole-linked 2'-deoxyuridines display remarkable hybridization-induced increases in fluorescence emission and enable efficient fluorescent discrimination of SNPs via G-specific quenching.

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