Journal
LABORATORY ANIMALS
Volume 34, Issue 1, Pages 84-90Publisher
ROYAL SOC MEDICINE PRESS LTD
DOI: 10.1258/002367700780578082
Keywords
anaesthesia; rats; chloral hydrate; intestinal contractions; adynamic ileus
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Chloral hydrate (CH) is used as an anaesthetic agent in laboratory rats. Side effects occurring with high concentrations have mainly occurred in abdominal organs. The objective of the present study was to minimize these side effects following intraperitoneal administration of CH using lower concentrations. Animals were evaluated using different procedures including a general necropsy, intraperitoneal white cell counts, histology and duodenal peristalsis and acetylcholine-induced contractions. Results clearly show that lower concentrations of CH while keeping the same anaesthetic dose (400 mg/kg) will minimize the irritancy of CH on abdonimal organs while providing the same level of anaesthesia.
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