4.7 Article

Highly enantioselective hydrogenation of alpha-aryl-beta-substituted acrylic acids catalyzed by Ir-SpinPHOX

Journal

CHEMICAL COMMUNICATIONS
Volume 46, Issue 1, Pages 156-158

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b919902k

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Funding

  1. NSFC [20632060, 20821002, 20620140429, 30772625]
  2. Chinese Academy of Sciences
  3. Major Basic Research Development Program of China [2010CB833300]
  4. Science and Technology Commission of Shanghai Municipality
  5. Merck Research Laboratories

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The enantioselective hydrogenation of a series of challenging substrates, alpha-aryl-beta-substituted acrylic acids, was realized with high efficiency and enantioselectivity (up to 96%) under the catalysis of Ir(I) complex of Spiro-based P,N ligand, SpinPHOX.

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