4.7 Article

Catalytic enantioselective aldol additions of alpha-isothiocyanato imides to alpha-ketoesters

Journal

CHEMICAL COMMUNICATIONS
Volume 46, Issue 25, Pages 4604-4606

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c0cc00556h

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Funding

  1. Rutgers, The State University of New Jersey

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A readily available bifunctional thiourea catalyst promotes aldol additions of alpha-isothiocyanato imides to alpha-ketoesters under mild reaction conditions to form beta-hydroxy-alpha-amino acid derivatives with high levels of enantioselectivity.

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