Journal
FASEB JOURNAL
Volume 14, Issue 12, Pages 1697-1704Publisher
FEDERATION AMER SOC EXP BIOL
DOI: 10.1096/fj.99-0869rev
Keywords
DNA methylation; linker histone modifications; nucleosomal DNA; transcription regulation
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Funding
- FOGARTY INTERNATIONAL CENTER [R03TW000568] Funding Source: NIH RePORTER
- FIC NIH HHS [TW00568] Funding Source: Medline
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In recent years, the connection between chromatin structure and its transcriptional activity has attracted considerable experimental effort. The post-translational modifications to both the core histones and the linker histones are finely tuned through interactions with transcriptional regulators and change chromatin structure in a way to allow transcription to occur. Here we review evidence for the involvement of linker histones in transcriptional regulation and suggest a scenario in which the reversible and controllable binding/displacement of proteins of this class to the nucleosome entry/exit point determine the accessibility of the nucleosomal DNA to the transcriptional machinery.
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