4.7 Article

Regioselective formation of interlocked dicarba bridges in naturally occurring cyclic peptide toxins using olefin metathesis

Journal

CHEMICAL COMMUNICATIONS
Volume -, Issue 28, Pages 4293-4295

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b909056h

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Funding

  1. Australian Postgraduate Research
  2. Australian Research Council

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Bis-dicarba analogues of native dicystine-containing alpha-conotoxin Rg1A, an analgesic peptide isolated from cone snail venom, were constructed on resin using a regioselective metathesis-hydrogenation strategy.

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