First total synthesis of antiostatin A1, a potent carbazole-based naturally occurring antioxidant

The first total synthesis of the potent antioxidant antiostatin A(1) is reported, where its key features rely on a chemo- and regioselective rhodium-catalysed crossed alkyne cyclotrimerisation reaction applying functionalised ynamides and a palladium-catalysed arylamidation reaction.