4.7 Article

Gd(DO3A-N-alpha-aminopropionate): a versatile and easily available synthon with optimized water exchange for the synthesis of high relaxivity, targeted MRI contrast agents

Journal

CHEMICAL COMMUNICATIONS
Volume -, Issue 42, Pages 6475-6477

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b912201j

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Funding

  1. Fundacao para a Ciencia e a Tecnologia, Portugal [PTDC/QUI/70063/2006, SFRH/BD/46370/2008]
  2. Rede Nacional de RMN [REDE/1517/RMN/2005]
  3. EU-FP6 [LSHC-2004-503569]

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We report the synthesis of a novel, versatile and easily accessible metal chelator, DO3A-N-alpha-aminopropionate, and the relaxometric characterization of its Gd3+ complex, revealing great potential for the development of high relaxivity targeted contrast agents for magnetic resonance imaging.

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