4.7 Article

Palladium-catalyzed aryl halide carbonylation-intramolecular O-enolate acylation: efficient isocoumarin synthesis, including the synthesis of thunberginol A

Journal

CHEMICAL COMMUNICATIONS
Volume -, Issue 44, Pages 6744-6746

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b917839b

Keywords

-

Funding

  1. EPSRC
  2. AstraZeneca
  3. Engineering and Physical Sciences Research Council [EP/C011074/2] Funding Source: researchfish

Ask authors/readers for more resources

Exposure of a series of alpha-(o-haloaryl)-substituted ketones to palladium-catalyzed carbonylation conditions leads to the formation of the corresponding isocoumarins. Balloon pressure of CO is sufficient to achieve high yielding reactions, and both cyclic and acyclic ketones are efficient substrates. The utility of the method is illustrated by a short synthesis of the natural product thunberginol A.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available