Journal
CHEMICAL COMMUNICATIONS
Volume -, Issue 44, Pages 6744-6746Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b917839b
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Funding
- EPSRC
- AstraZeneca
- Engineering and Physical Sciences Research Council [EP/C011074/2] Funding Source: researchfish
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Exposure of a series of alpha-(o-haloaryl)-substituted ketones to palladium-catalyzed carbonylation conditions leads to the formation of the corresponding isocoumarins. Balloon pressure of CO is sufficient to achieve high yielding reactions, and both cyclic and acyclic ketones are efficient substrates. The utility of the method is illustrated by a short synthesis of the natural product thunberginol A.
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