4.7 Article

Palladium-catalysed enantioselective alpha-hydroxylation of beta-ketoesters

Journal

CHEMICAL COMMUNICATIONS
Volume -, Issue 26, Pages 3925-3927

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b907151b

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Funding

  1. EPSRC (DTA)
  2. Pfizer

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Highly enantioselective alpha-hydroxylation of cyclic and acyclic 1,3-ketoesters can be achieved with up to 98% ee using a dicationic palladium(II) catalyst and dimethyldioxirane as oxidant.

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