4.7 Article

Rhodium catalyzed enantioselective cyclization of substituted imidazoles via C-H bond activation

Journal

CHEMICAL COMMUNICATIONS
Volume -, Issue 26, Pages 3910-3912

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b902878a

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Funding

  1. National Institutes of Health [GM069559]
  2. Office of Basic Energy Sciences, Chemical Sciences Division, US Department of Energy [DE-AC02-05CH11231]
  3. NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM069559] Funding Source: NIH RePORTER

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The enantioselective intramolecular alkylation of substituted imidazoles with enantiomeric excesses up to 98% has been accomplished by rhodium catalyzed C-H bond functionalization with (S, S', R, R') TangPhos as the chiral ligand.

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