4.7 Article

Nickel(0)-catalyzed [2+2+2] cycloaddition of diynes and 3,4-pyridynes: novel synthesis of isoquinoline derivatives

Journal

CHEMICAL COMMUNICATIONS
Volume -, Issue 35, Pages 5245-5247

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b912022j

Keywords

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Funding

  1. JSPS [19390001]
  2. MEXT, Japan [19028001, 20037002]
  3. Novartis Foundation (Japan) for the Promotion of Science
  4. Uehara Memorial Foundation
  5. Akiyama Foundation

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A transition metal-catalyzed [2 + 2 + 2] cycloaddition between alpha,omega-diynes and 3,4-pyridynes has been realized for the first time, producing isoquinolines in good yields by using a nickel(0) catalyst.

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