Journal
CHEMICAL COMMUNICATIONS
Volume -, Issue 31, Pages 4705-4707Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b909698a
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Funding
- Ministerio de Educacion y Ciencia [CTQ2005-01834, CTQ2007-68014, CTQ2008-02064]
- Generalitat de Catalunya [2005SGR-693]
- Programa d'Intensificaciode la Recerca (UB)
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The first dichloroplatinum(II) conjugates of dicarba analogues of octreotide, which is expected to act as a 'tumour-targeting device', have been efficiently synthesized following a stepwise solid-phase approach; these compounds emulate the mechanism of cisplatin since they form a 1,2-intrastrand cross-link with two consecutive guanines of an oligonucleotide.
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