4.7 Article

Palladium-catalyzed amidation-hydrolysis reaction of gem-dihaloolefins: efficient synthesis of homologated carboxamides from ketones

Journal

CHEMICAL COMMUNICATIONS
Volume -, Issue 22, Pages 3246-3248

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b904991f

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A simple and efficient palladium-catalyzed amidation-hydrolysis reaction has been developed to afford N-aryl monosubstituted carboxamides in good to excellent yields from easily accessible ketone-derived gem-dihaloolefins and aryl amines.

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