4.7 Article

Molecular combo of photodynamic therapeutic agent silicon(IV) phthalocyanine and anticancer drug cisplatin

Journal

CHEMICAL COMMUNICATIONS
Volume -, Issue 8, Pages 908-910

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b817968a

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Funding

  1. National Science Foundation of China [20631020, 90713001, 20721002]
  2. Natural Science Foundation of Jiangsu Province [BK2008015]

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The combination of a red light PDT agent and a Pt(II)-based chemotherapeutic drug at the molecular level maintains the intrinsic functions of each unit; the conjugated complexes exhibit remarkable photocytoxicity and demonstrate potential to serve as agents for DNA-targeting PDT as well as red light photochemotherapy.

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