4.7 Article

Fast, copper-free click chemistry: a convenient solid-phase approach to oligonucleotide conjugation

Journal

CHEMICAL COMMUNICATIONS
Volume -, Issue 22, Pages 3276-3278

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b904185k

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Funding

  1. Science Foundation of Ireland [05/PICA/B838]

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Solid-phase oligonucleotide conjugation by nitrile oxide-alkyne click cycloaddition chemistry has been successfully demonstrated; the reaction, compatible with all nucleobases, requires no metal catalyst and proceeds under physiological conditions.

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