4.7 Article

Base and copper(I) catalyzed Mannich, alkyne hydroamination cascades for the direct synthesis of 2-methylenepyrrolidines

Journal

CHEMICAL COMMUNICATIONS
Volume -, Issue 26, Pages 3916-3918

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b905629g

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Funding

  1. Universities UK
  2. University of Manchester
  3. AstraZeneca
  4. National Natural Science Foundation of China (NSFC) [20772051]

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An efficient, simple-to-perform, one-pot reaction cascade to 2-methylenepyrrolidines from p-toluenesulfonyl protected imines and propargylated malonates under a combination of base and copper(I) catalysis is reported.

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