4.7 Article

Sensitive and efficient detection of thrombus with fibrin-specific manganese nanocolloids

Journal

CHEMICAL COMMUNICATIONS
Volume -, Issue 22, Pages 3234-3236

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b902875g

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Funding

  1. AHA [0835426N]
  2. NIH [NS059302, CA119342, HL073646]
  3. NCI [N01CO37007]
  4. NATIONAL CANCER INSTITUTE [U54CA119342] Funding Source: NIH RePORTER
  5. NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL073646] Funding Source: NIH RePORTER
  6. NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS059302] Funding Source: NIH RePORTER

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In this work, we report novel fibrin targeted soft-type'' manganese-based contrast agents for MRI with the potential to noninvasively image intravascular thrombus which could warrant aggressive medical intervention to preclude subsequent myocardial infarction or stroke.

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