4.7 Article

Molecular recognition of a thymine bulge by a high affinity, deazaguanine- based hydrogen-bonding ligand

Journal

CHEMICAL COMMUNICATIONS
Volume -, Issue 6, Pages 668-670

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b817733n

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Funding

  1. National Science Foundation
  2. National Institutes of Health

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7-Deazaguanine (7-DeG) was developed as a hydrogen-bonding module capable of enhanced recognition of uracil (U) and thymine (T); a water-soluble derivative displayed high affinity and selectivity toward DNA and RNA duplexes containing single T-and U-bulges.

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