4.7 Article

Highly enantioselective 1,3-dipolar cycloaddition of azomethine ylides catalyzed by AgOAc/TF-BiphamPhos

Journal

CHEMICAL COMMUNICATIONS
Volume -, Issue 20, Pages 2905-2907

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b902556a

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Funding

  1. National Natural Science Foundation of China [J0730426]
  2. Wuhan University

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A novel and highly efficient AgOAc/TF-BiphamPhos catalytic system shows excellent reactivity, diastereo-/enantioselectivity and structural scope in asymmetric 1,3-dipolar cycloaddition of azomethine ylides, especially derived from various alpha-substituted alpha-amino acids, with N-substituted maleimides and other electron-deficient alkenes.

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