Journal
SCIENCE
Volume 289, Issue 5484, Pages 1546-1550Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.289.5484.1546
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The atomic structures of two proteins in the histidine biosynthesis pathway consist of beta/alpha barrels with a twofold repeat pattern. It is Likely that these proteins evolved by twofold gene duplication and gene fusion from a common half-barrel ancestor. These ancestral domains are not visible as independent domains in the extant proteins but can be inferred from a combination of sequence and structural analysis. The detection of subdomain structures may be useful in efforts to search genome sequences for functionally and structurally related proteins.
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