4.7 Article

Boiling water-catalyzed neutral and selective N-Boc deprotection

Journal

CHEMICAL COMMUNICATIONS
Volume -, Issue 34, Pages 5144-5146

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b910239f

Keywords

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Funding

  1. National Natural Science Foundation of China [20402007, 20772065]
  2. 111 Project [B06005]
  3. 863 Project of the Ministry of Science and Technology of China [2006AA020502]

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A general protocol for removing Boc groups from various types of nitrogen is reported and a preliminary investigation of the reaction mechanism indicates that water acts as a dual acid/base catalyst at elevated temperature.

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