Journal
CHEMICAL COMMUNICATIONS
Volume -, Issue 44, Pages 6756-6758Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b917312a
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Funding
- Idaho NSF EPSCoR
- BANTech Center at the Univ. of Idaho
- University of Idaho Research Office and Research Council Seed Grant
- National Institutes of Health
- National Center for Research Resources [P20 RR016448]
- College of Graduate Studies
- NATIONAL CENTER FOR RESEARCH RESOURCES [P20RR016448] Funding Source: NIH RePORTER
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Triplex forming oligonucleotides (TFOs) modified with C5-alkynyl functionalized LNA (locked nucleic acid) monomers display extraordinary thermal affinity toward double stranded DNA targets, excellent discrimination of Hoogsteen-mismatched targets, and high stability against 3'-exonucleases.
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