Journal
JOURNAL OF IMMUNOLOGY
Volume 165, Issue 5, Pages 2331-2334Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.165.5.2331
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Funding
- NATIONAL CANCER INSTITUTE [P30CA016042] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI040118] Funding Source: NIH RePORTER
- NCI NIH HHS [CA16042] Funding Source: Medline
- NIAID NIH HHS [AI40118] Funding Source: Medline
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Galectin-1, an endogenous lectin expressed in lymphoid organs and immune-privileged sites, induces death of human and murine thymocytes and T cells. Galectin-1 binds to several glycoproteins on the T cell surface, including CD7, However, the T cell surface glycoprotein receptors responsible for delivering the galectin-1 death signal have not been identified, We show that CD7 is required for galectin-1-mediated death. This demonstrates a novel function for CD7 as a death trigger and identifies galectin-1/CD7 as a new biologic death signaling pair.
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