4.7 Article

Inhibition of selectin binding by colloidal gold with functionalized shells

Journal

CHEMICAL COMMUNICATIONS
Volume -, Issue 8, Pages 932-934

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b818263a

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Funding

  1. Deutsche Forschungsgemeinschaft (SFB 765)
  2. Alexander von Humboldt-Stiftung

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Gold colloids with terminally functionalized sulfated thiol shells were found to bind to P- and L-selectins with IC50 values in the picomolar range; branched acyclic epitopes show the highest affinity, whereas a sulfated carbohydrate mimetic provides the best selectivity.

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