4.7 Article

One-pot cross-coupling of N-acyl N,O-acetals with alpha,beta-unsaturated compounds

Journal

CHEMICAL COMMUNICATIONS
Volume -, Issue 45, Pages 7045-7047

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b915488d

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Funding

  1. NSF of China [20402012, 20832005]
  2. National Basic Research Program (973 Program) of China [2010CB833206]
  3. Program for New Century Excellent Talents in Xiamen University

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The synergistic action of BF3 center dot OEt2 and SmI2 allowed a series of intermolecular cross-couplings of readily available N-acyl N,O-acetals with alpha,beta-unsaturated compounds to be performed in high yields, which was applied to the stereoselective synthesis of pyrrolizidine alkaloid (+)-xenovenine.

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