4.7 Article

Disulfide-cross-linked PEG-poly(amino acid)s copolymer micelles for glutathione-mediated intracellular drug delivery

Journal

CHEMICAL COMMUNICATIONS
Volume -, Issue 48, Pages 6570-6572

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b815918a

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Funding

  1. Ministry of Education, Science and Technology, Korea [08K1501-01110]
  2. Ministry of Knowledge Economy, Korea

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We report biocompatible, cell-permeable core-shell-corona polymer micelles bearing glutathione-cleavable shell cross-links, which allow the facilitated release of entrapped anticancer drugs at cytoplasm in response to an intracellular glutathione level.

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