Synthesis of N-protected alpha-amino aldehydes from their morpholine amide derivatives

A new method for the synthesis of N-protected alpha-amino aldehydes was developed. N-Protected alpha-amino amides of morpholine were easily prepared and then reduced with LiAlH4 to produce clean N-protected alpha-amino aldehydes. This new scheme of synthesis can be used with Boc, Z and Fmoc amino-protecting groups. (C) 1999 Elsevier Science Ltd. All rights reserved.