Journal
CHEMICAL COMMUNICATIONS
Volume -, Issue 36, Pages 4250-4260Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b806854m
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Funding
- GRL project of MEST
- Intramural Research Program of the KIST and the Korea Health 21 RD Project
- Ministry of Health & Welfare, Republic of Korea [A062254]
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Current optical imaging probe applications are hampered by poor sensitivity and specificity to the target, but molecular-level fluorescent signal activation strategies can efficiently overcome these limitations. Recent interdisciplinary research that couples the imaging sciences to fluorophore, peptide, polymer and inorganic-based chemistry has generated novel imaging probes that exhibit high sensitivity and low background noise in both in vitro and in vivo applications. This feature article introduces and discusses the various approaches described by the term fluorescent signal activation methods with respect to their unique imaging probe design strategies and applications.
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