Journal
JOURNAL OF IMMUNOLOGY
Volume 164, Issue 1, Pages 1-4Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.164.1.1
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Polycomb group (Pc-G) proteins regulate homeotic gene expression in Drosophila, mouse, and humans, Mouse Pc-G proteins are also essential for adult hematopoietic development and contribute to cell cycle regulation. We show that human Pc-G expression patterns correlate with different B cell differentiation stages and that they reflect germinal center (GC) architecture. The transition of resting mantle B cells to rapidly dividing Mib-1(Ki-67)(+) follicular centroblasts coincides with loss of BMI-1 and RING1 Pc-G protein detection and appearance of ENX and EED Pc-G protein expression. By contrast, differentiation of centroblasts into centrocytes correlates with reappearance of BMI-1/RING1 and loss of ENX/EED and Mib-1 expression. The mutually exclusive expression of ENX/ EED and BMI-1/RING1 reflects the differential composition of two distinct Pc-G complexes, The Pc-G expression profiles in various GC B cell differentiation stages suggest a role for Pc-G proteins in GC development.
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