4.7 Article

Bisucaberin biosynthesis: an adenylating domain of the BibC multi-enzyme catalyzes cyclodimerization of N-hydroxy-N-succinylcadaverine

Journal

CHEMICAL COMMUNICATIONS
Volume -, Issue 41, Pages 5119-5121

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b813029a

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Funding

  1. UK BBSRC [BB/S/B14450]
  2. Biotechnology and Biological Sciences Research Council [BBS/B/14450] Funding Source: researchfish

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The bisucaberin biosynthetic gene cluster has been identified in Vibrio salmonicida and a domain from within the BibC multienzyme encoded by the cluster has been shown to catalyse ATP-dependent dimerisation and macrocyclisation of N-hydroxy-N-succinylcadaverine to form bisucaberin.

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