4.7 Article

Crystal structure of tricyclo-DNA: an unusual compensatory change of two adjacent backbone torsion angles

Journal

CHEMICAL COMMUNICATIONS
Volume -, Issue 7, Pages 883-885

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b716390h

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Funding

  1. NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM055237] Funding Source: NIH RePORTER
  2. NIGMS NIH HHS [GM 55237] Funding Source: Medline

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The crystal structure of a DNA duplex with tricyclo-DNA (tc-DNA) residues explains the increased RNA affinity of tc-DNA relative to DNA and tc-DNA's superior resistance to nucleases.

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