Journal
FEBS LETTERS
Volume 480, Issue 2-3, Pages 193-196Publisher
WILEY
DOI: 10.1016/S0014-5793(00)01922-0
Keywords
aspirin; non-steroidal anti-inflammatory drug; apoptosis; cytochrome c; mitochondrion; caspase
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Aspirin and other non-steroidal anti-inflammatory drugs induce apoptosis in many cell types. Although the involvement of caspases has been demonstrated, the mechanism leading to caspase activation remains unknown. We have studied the role of the mitochondrial pathway in aspirin-induced apoptosis, The apoptotic effect of aspirin was analyzed in different cell lines (Jurkat, MOLT-4, Raji and HL-60) showing induction of mitochondrial cytochrome c release and caspases 9, 3 and 8 processing. Furthermore, early aspirin-induced cytochrome c release was not affected by the caspase inhibitor Z-VAD-fmk and preceded loss of mitochondrial membrane potential. Therefore, aspirin-induced apoptosis involves caspase activation through cytochrome c release. (C) 2000 Federation of European Biochemical Societies, Published by Elsevier Science B.V. All rights reserved.
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