Journal
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
Volume 105, Issue 3, Pages 421-429Publisher
MOSBY, INC
DOI: 10.1067/mai.2000.105010
Keywords
dendritic cells; immunoregulation; T(H)1/2; T-cell activation; inflammation
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Dendritic cells are now recognized as the gatekeepers of the immune response, possessing a unique potential for acquisition of antigens at extremely low exposure levels and for efficient presentation of these in an immunogenic form to the naive T-cell system. Dendritic cell populations throughout the body exhibit a wide range of features in common that are associated with their primary functions, and these are considered in the initial section of this review. In addition, it is becoming evident that the properties and functions of these cells are refined by microenvironmental factors unique to their tissues of residence, a prime ex-ample being mucosal microenvironments such as those in respiratory tract tissues, and the latter represents the Focus of the second section of this review.
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