Novel approach for the synthesis of Fe3O4@TiO2 core-shell microspheres and their application to the highly specific capture of phosphopeptides for MALDI-TOF MS analysis

A novel approach is proposed to synthesize Fe3O4@TiO2 microspheres with a well-defined core-shell structure, and the synthesized Fe3O4@TiO2 core-shell microspheres were successfully applied for the simple and fast enrichment of phospho-peptides via direct MALDI-TOF mass spectrometry analysis.