Journal
INFECTION AND IMMUNITY
Volume 68, Issue 3, Pages 1710-1713Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.68.3.1710-1713.2000
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Funding
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [P01DK035108] Funding Source: NIH RePORTER
- NIDDK NIH HHS [DK35108, P01 DK035108] Funding Source: Medline
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Cryptosporidium parvum induces moderate levels of apoptosis of cultured human intestinal epithelial cells which are maximal at 24 h after infection. Apoptosis is further increased in C. parvum-infected cell by inhibition of NF-KB. C. parvum infection also attenuates epithelial apoptosis induced by strongly proapoptotic agents. The data suggest C. parvum has developed strategies to limit apoptosis in order to facilitate its growth and maturation in the early period after epithelial cell infection.
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