4.7 Article

One-pot approach for the synthesis of trans-cyclopropyl compounds from aldehydes. Application to the synthesis of GPR40 receptor agonists

Journal

CHEMICAL COMMUNICATIONS
Volume -, Issue 40, Pages 4974-4976

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b810708d

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Funding

  1. NSERC (Canada)
  2. Canada Foundation for Innovation
  3. Boehringer Ingelheim (Canada) Ltee
  4. Merck Frosst
  5. Universite de Montreal

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A novel multicatalytic one-pot process providing trans-cyclopropyl compounds from corresponding aldehydes has been developed and applied to the synthesis of GPR40 small molecule agonists.

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