Journal
INFECTION AND IMMUNITY
Volume 68, Issue 3, Pages 1706-1709Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.68.3.1706-1709.2000
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Funding
- NIAID NIH HHS [R01 AI044072, AI-75320, AI-44072] Funding Source: Medline
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [N01AI075320, R01AI044072] Funding Source: NIH RePORTER
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Two vaccine formulations previously shown to induce protective immunity in mice and prevention of longterm necrosis in guinea pigs were tested as potential immunotherapeutic vaccines in mice earlier infected by aerosol with Mycobacterium tuberculosis. Neither vaccine had any effect on the course of the infection in the lungs, but both reduced the bacterial load in the spleen. Similarly, inoculation with inoculation with Mycobacterium bovis BCG had no effect whatsoever and, if given more than once, appeared to induce an increasingly severe pyogranulomatous response in the lungs of these mice.
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