Journal
JOURNAL OF VIROLOGY
Volume 74, Issue 6, Pages 2814-2825Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.74.6.2814-2825.2000
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Funding
- NIAID NIH HHS [R01 AI033952, AI-33952] Funding Source: Medline
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI033952] Funding Source: NIH RePORTER
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Cellular pre-mRNA splicing is inhibited by ICP27, a herpes simplex virus regulatory protein, resulting in the shutoff of host protein synthesis. Here we reveal that ICP27 also mediates the export of some virus RNAs via a Crm1-dependent pathway and present evidence that independent domains are required for these functions. Sorting of some viral mRNAs for nuclear export requires Crm1, while other virus mRNAs are exported via another pathway.
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