Synthesis and comparative lectin-binding affinity of mannosyl-coated beta-cyclodextrin-dendrimer constructs

Targeted drug delivery systems have been built from beta-cyclodextrin by monoconjugation with mannosyl-coated dendritic branches following an iterative thiourea-forming convergent strategy; the multivalent adducts showed high Concanavalin A lectin binding ability and intact inclusion capabilities.